Protein Information

Name Hageman factor
Synonyms Coagulation factor XII; Coagulation factor XII precursor; Coagulation factor XII Mie; F12; F12 protein; Factor XII; HAF; Hageman factor…

Compound Information

Name diatomaceous earth
CAS diatomite

Reference List

PubMed Abstract RScore(About this table)
4241814 Ogston D, Ogston CM, Ratnoff OD, Forbes CD: Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors. J Clin Invest. 1969 Oct;48(10):1786-801.

The defect could be repaired by addition of a noneuglobulin fraction of plasma or an agent or agents eluted from diatomaceous earth which had been exposed to normal plasma.
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180627 Zubairov DM, Popova LG: New evidence for the activation of factor XII by epinephrine. Thromb Res. 1976 May;8(5):587-97.

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862236 Fesus L, Csaba B, Muszbek L: Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis. Clin Exp Immunol. 1977 Mar;27(3):512-5.

Platelet-activating factor (PAF) generated by an IgE-mediated reaction in the peritoneal cabity of rats was partially purified by adsorption to diatomaceous earth.
It aggregated rat platelets and, as a consequence, activated Hageman factor in in vitro, as well as in vivo, conditions.
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