Protein Information

Name plasminogen
Synonyms A; Apo(a); APOA2; Plasminogen; APOA 2; Angiostatin; Apolipoprotein A II; Microplasmin…

Compound Information

Name diatomaceous earth
CAS diatomite

Reference List

PubMed Abstract RScore(About this table)
6270665 Husain SS, Lipinski B, Greuwich V: Rapid purification of a high-affinity plasminogen activator from human blood plasma by specific adsorption on fibrin/Celite. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4265-9.

A preparation of fibrin precipitated over a solid Celite (diatomaceous earth) matrix that selectively binds 50-70% of the plasminogen activator present in human blood plasma is described.
36(0,1,1,6) Details
4241814 Ogston D, Ogston CM, Ratnoff OD, Forbes CD: Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors. J Clin Invest. 1969 Oct;48(10):1786-801.

The defect could be repaired by addition of a noneuglobulin fraction of plasma or an agent or agents eluted from diatomaceous earth which had been exposed to normal plasma.
2(0,0,0,2) Details
17045938 Nielsen VG, Steenwyk BL, Gurley WQ: Contact activation prolongs clot lysis time in human plasma: role of thrombin-activatable fibrinolysis inhibitor and Factor XIII. J Heart Lung Transplant. 2006 Oct;25(10):1247-52.


BACKGROUND: Contact activation system proteins (e.g., Factor XII, kallikrein) have been implicated as direct or indirect activators of plasminogen.
1(0,0,0,1) Details