Protein Information

Name thromboplastin
Synonyms CD142; TF; F3; CD142 antigen; Coagulation Factor 3; Coagulation factor III; TFA; Thromboplastin…

Compound Information

Name diatomaceous earth
CAS diatomite

Reference List

PubMed Abstract RScore(About this table)
6748609 Mrema JE, Johnson GS, Kelley ST, Green TJ: Activated partial thromboplastin time of owl monkey (Aotus trivirgatus) plasma. Lab Anim Sci. 1984 Jun;34(3):295-8.

The discrepant data could not be explained by differences in anticoagulants (citrate or oxalate), assay reagents (partial thromboplastin with either diatomaceous earth or ellagic acid), or activation incubation times (2, 5, or 10 minutes); nor could they be explained by differences in the monkeys' sex, age or previous experimental exposure to Plasmodium falciparum malaria.
3(0,0,0,3) Details
11684986 Avidan MS, Da Fonseca J, Parmar K, Alcock E, Ponte J, Hunt BJ: The effects of aprotinin on thromboelastography with three different activators. Anesthesiology. 2001 Nov;95(5):1169-74.


Aprotinin, through inhibition of kallikrein, causes prolongation of the celite-activated clotting time and the activated partial thromboplastin ratio.
2(0,0,0,2) Details
7529949 Feindt P, Seyfert UT, Volkmer I, Straub U, Gams E: Celite and kaolin produce differing activated clotting times during cardiopulmonary bypass under aprotinin therapy. Thorac Cardiovasc Surg. 1994 Aug;42(4):218-21.


These results were confirmed in ex-vivo experiments using an activated partial thromboplastin time (aPTT) model.
1(0,0,0,1) Details
1538250 Reich DL, Zahl K, Perucho MH, Thys DM: An evaluation of two activated clotting time monitors during cardiac surgery. J Clin Monit. 1992 Jan;8(1):33-6.

The Hemochron ACT monitor (HCH; International Technidyne, Inc, Edison, NJ) was evaluated using 2.0 ml of whole blood in glass tubes with diatomaceous earth activator.
Following sternotomy, a coagulation profile consisting of HTC, HCH, and a partial thromboplastin time (PTT) was obtained (T0).
1(0,0,0,1) Details
8236136 Tripodi A, Chantarangkul V, Arbini AA, Moia M, Mannucci PM: Effects of hirudin on activated partial thromboplastin time determined with ten different reagents. Thromb Haemost. 1993 Aug 2;70(2):286-8.

1(0,0,0,1) Details