| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | silica gel |
|---|---|
| CAS | silica gel |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19349754 | Kim JH, Lee CH: Rengyolone inhibits apoptosis via etoposide-induced caspase downregulation. J Microbiol Biotechnol. 2009 Mar;19(3):286-90. The regulating compounds were purified from the ethyl extract by silica gel column chromatography and HPLC. This compound showed inhibitory activity on caspase-3 induction, a major protease of the apoptosis cascade, with an IC50 value of 38.96 microM after 8 h of etoposide treatment in U937 cells. |
2(0,0,0,2) | Details |
| 17424944 | Yoo YC, Shin BH, Hong JH, Lee J, Chee HY, Song KS, Lee KB: Isolation of fatty acids with anticancer activity from Protaetia brevitarsis larva. Arch Pharm Res. 2007 Mar;30(3):361-5. From a silica gel column chromatograpy of this extract, we obtained four fractions (F-2, F-4, F-5 and F-7) having apoptosis-inducing activity. These fractions induced DNA ladder and caspase-3 activation during apoptosis in colon 26 tumor cells. |
2(0,0,0,2) | Details |
| 19897545 | Yao CJ, Yang CM, Chuang SE, Yan JL, Liu CY, Chen SW, Yan KH, Lai TY, Lai GM: Targeting PML-RAR{alpha} and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evid Based Complement Alternat Med. 2009 Nov 23. By using ethyl extraction and silica gel chromatography, an active fraction of THL named as EAS5 was isolated. The THL-induced apoptosis was accompanied with caspase-3 activation and decrease of PML-RARalpha fusion protein. |
1(0,0,0,1) | Details |
| 16688796 | Choedon T, Mathan G, Arya S, Kumar VL, Kumar V: Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma. World J Gastroenterol. 2006 Apr 28;12(16):2517-22. The methanolic extract was sub-fractionated on a silica gel G column using a combination of non-polar and polar solvents and eleven fractions were obtained. Finally, the mechanism of cell death was investigated by measuring the levels of Bcl2, caspase 3 and DNA fragmentation. |
1(0,0,0,1) | Details |
| 19322700 | Kang TJ, Lee SY, Singh RP, Agarwal R, Yim DS: Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncol. 2009;48(6):895-900. Oxypeucedanin-induced cell death was associated with significant increases in apoptosis and cleaved caspase-3 and poly-(ADP- polymerase. MATERIAL AND METHODS: Oxypeucedanin (C (16) H (14) O (5), mw: 286) was isolated through silica gel chromatography and characterized by NMR. |
1(0,0,0,1) | Details |