| Name | CYP3A4 |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | silica gel |
|---|---|
| CAS | silica gel |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16719384 | Waxman DJ, Chang TK: Thin-layer chromatography analysis of human CYP3A-catalyzed 6beta-hydroxylation. Methods Mol Biol. 2006;320:133-41. A thin-layer chromatographic method is described for the determination of 6beta-hydroxytestosterone formed enzymatically by incubation of [14C]- with cDNA-expressed CYP3A enzymes or liver microsomes. 14C-labeled enzymatic products are applied to silica gel thin-layer plates, which are developed sequentially with methylene chloride:acetone (80:20) followed by chloroform, ethyl and (80:20:14). |
84(1,1,1,4) | Details |
| 17540708 | Cai P, Tsao R, Ruppen ME: In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites. Drug Metab Dispos. 2007 Sep;35(9):1554-63. Epub 2007 May 31. The in vitro metabolism of temsirolimus, (rapamycin-42-[2,2-bis-(hydroxymethyl)]- an antineoplastic agent, was studied using human liver microsomes as well as recombinant human cytochrome P450s, namely CYP3A4, 1A2, 2A6, 2C8, 2C9, 2C19, and 2E1. By silica gel chromatography followed by semipreparative reverse-phase high-performance liquid chromatography, individual metabolites were separated and purified for structural elucidation and bioactivity studies. |
3(0,0,0,3) | Details |