Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name silica gel
CAS silica gel

Reference List

PubMed Abstract RScore(About this table)
17301064 Jun DY, Kim JS, Park HS, Han CR, Fang Z, Woo MH, Rhee IK, Kim YH: Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade. Carcinogenesis. 2007 Jun;28(6):1303-13. Epub 2007 Feb 13.

An apoptogenic ingredient in the methylene chloride extract was further purified by silica gel column chromatography and identified as auraptene (AUR).
After the treatment of Jurkat T cells with AUR, the endoplasmic reticulum (ER) stress-mediated activation of caspase-12 and -8 and subsequent apoptotic events including c-Jun N-terminal kinase (JNK) activation, cleavage of FLICE inhibitory protein and Bid, mitochondrial cytochrome c release, activation of caspase-9 and -3, degradation of poly (ADP-ribose) polymerase and apoptotic DNA fragmentation were induced in a dose-dependent manner.
1(0,0,0,1) Details
18264700 Pasilis SP, Kertesz V, Van Berkel GJ, Schulz M, Schorcht S: Using HPTLC/DESI-MS for peptide identification in 1D separations of tryptic protein digests. Anal Bioanal Chem. 2008 May;391(1):317-24. Epub 2008 Feb 9.

Desorption electrospray ionization mass spectrometry (DESI-MS) was investigated as a method to detect and identify peptides from tryptic digests of cytochrome c and myoglobin separated on ProteoChrom HPTLC Silica gel 60 F (254s) plates and ProteoChrom HPTLC Cellulose sheets.
12(0,0,2,2) Details
18447365 Shibayama N: Slow motion analysis of protein folding intermediates within wet silica gels. Biochemistry. 2008 May 27;47(21):5784-94. Epub 2008 May 1.

Here, we show that entrapment of the protein cytochrome c in wet, optically transparent, porous silica gel matrices has enabled a dramatic expansion, to days or weeks, of the folding time, allowing direct observation of the entire folding pathway using a combination of three spectroscopic techniques, far-ultraviolet circular dichroism, tryptophan fluorescence, and Soret absorption spectroscopy.
8(0,0,1,3) Details
17674423 Yu J, Liu H, Lei J, Tan W, Hu X, Zou G: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytother Res. 2007 Sep;21(9):817-22.

CE-SB was subjected to bioassay-guided isolation of the active compounds by chromatography on silica gel and Sephadex LH-20.
Treatment with CE-SB caused cytochrome c release and activation of caspase-9.
1(0,0,0,1) Details