| Name | ACAT |
|---|---|
| Synonyms | ACAT; Cholesteryl ester hydrolase; CES1; SES 1; SES1; ANAE; Acid esterase; Acyl coenzyme A cholesterol acyltransferase… |
| Name | silica gel |
|---|---|
| CAS | silica gel |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15974439 | Kim DH, Jung SJ, Chung IS, Lee YH, Kim DK, Kim SH, Kwon BM, Jeong TS, Park MH, Seoung NS, Baek NI: peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent. Arch Pharm Res. 2005 May;28(5):541-5. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activity-guided fractionation, using ACAT inhibitory activity measurements. |
31(0,1,1,1) | Details |
| 17803269 | Tomoda H, Doi T: Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. Acc Chem Res. 2008 Jan;41(1):32-9. Epub 2007 Sep 6. FO-6979, a soil isolate, by solvent extraction, ODS column chromatography, silica gel column chromatography, and preparative HPLC. Study on the mechanism of action revealed that beauveriolides inhibited macrophage acyl-CoA:cholesterol acyltransferase (ACAT) activity to block the synthesis of ester (CE), leading to a reduction of lipid droplets in macrophages. |
3(0,0,0,3) | Details |
| 17146959 | Ahn EM, Bang MH, Song MC, Park MH, Kim HY, Kwon BM, Baek NI: Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of Ixeris dentata forma albiflora. Arch Pharm Res. 2006 Nov;29(11):937-41. Eight sesquiterpenes were isolated through repeated silica gel and octadecyl silica gel (C18, ODS) column chromatography of the EtOAc and n-BuOH fractions. |
2(0,0,0,2) | Details |