Protein Information

Name c fos
Synonyms Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
10072926 Che JT, Zhang JT, Qu ZW, Wei G: Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. . Zhongguo Yao Li Xue Bao. 1997 Jul;18(4):371-3.

Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner.
200(2,3,4,5) Details
7531829 Tusell JM, Barron S, Serratosa J: Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. Neurotoxicology. 1994 Fall;15(3):751-6.
63(0,2,2,3) Details
1382176 Vendrell M, Pujol MJ, Tusell JM, Serratosa J: Effect of different convulsants on calmodulin levels and proto-oncogene c-fos expression in the central nervous system. Brain Res Mol Brain Res. 1992 Aug;14(4):285-92.

In the present study, a relationship between convulsant activity and two cellular events, changes in calmodulin (CaM) concentration and proto-oncogene c-fos expression has been considered. c-fos has been found activated after the administration of the organochlorine insecticide lindane, the Ca2+ channel agonist Bay K, and N-methyl-D-aspartate (NMDA).
35(0,1,1,5) Details
7534335 Barron S, Serratosa J, Tusell JM: Regulation of c-fos expression by convulsants and hexachlorocyclohexane isomers in primary cultures of cortical neurons. J Neurochem. 1995 Apr;64(4):1708-14.

Lindane (gamma-hexachlorocyclohexane), Bay K 8644, pentylenetetrazole, and picrotoxinin produced a significant increase in c-fos immunoreactivity and in c-fos mRNA expression.
13(0,0,1,8) Details
1710164 Vendrell M, Zawia NH, Serratosa J, Bondy SC: c-fos and ornithine decarboxylase gene expression in brain as early markers of neurotoxicity. Brain Res. 1991 Mar 29;544(2):291-6.

An increase of proto-oncogene c-fos expression in cerebral cortex of rats treated with subconvulsant doses of the pesticide organochlorine lindane (gamma-hexachlorocyclohexane) has been detected using Northern blots.
9(0,0,1,4) Details
1371151 Vendrell M, Tusell JM, Serratosa J: c-fos expression as a model for studying the action of hexachlorocyclohexane isomers in the CNS. J Neurochem. 1992 Mar;58(3):862-9.

The organochlorine insecticide gamma-hexachlorocyclohexane (gamma-HCH, lindane) has been shown to induce c-fos expression in different brain areas.
9(0,0,1,4) Details
1380685 Vendrell M, Tusell JM, Serratosa J: Effect of gamma-hexachlorocyclohexane and its isomers on proto-oncogene c-fos expression in brain. Neurotoxicology. 1992 Spring;13(1):301-8.

The organochlorine insecticide gamma-hexachlorocyclohexane (lindane) has been shown to induce c-fos expression in a dose dependent manner. 30 mg/kg of lindane increased c-fos expression in cortical and hippocampal areas.
9(0,0,1,4) Details