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Kasuya A, Sawada Y, Tsukamoto Y, Tanaka K, Toya T, Yanagi M: Binding mode of ecdysone agonists to the receptor: comparative modeling and docking studies. J Mol Model. 2003 Feb;9(1):58-65. Epub 2003 Jan 14.
Two models were created based both on known ligand-binding domain structures of the receptors with the highest sequence identity to the ecdysone receptor, and on those of steroid hormone receptors.
The docking of a dibenzoylhydrazine agonist, chromafenozide, was performed based on the correspondences between the molecule and 20-dydroxyecdysone expected by molecular comparison. |
2(0,0,0,2) |
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