Protein Information

Name Hsp70
Synonyms APG 2; APG2; HS24/P52; HSP70RY; HSPA 4; HSPA4; Heat shock 70 kDa protein 4; Heat shock 70 related protein APG 2…

Compound Information

Name copper arsenate
CAS

Reference List

PubMed Abstract RScore(About this table)
17945439 Scharf B, Trombetta LD: The effects of the wood preservative copper dimethyldithiocarbamate in the hippocampus of maternal and newborn Long-Evans rats. Toxicol Lett. 2007 Nov 1;174(1-3):117-24. Epub 2007 Sep 14.

The potential toxic effects on human health and deleterious effects to the environment by copper dimethyldithiocarbamate (CDDC), an alternative wood preservative to chromated copper arsenate (CCA) have not been investigated.
Western blot analysis revealed an induction of stress proteins HO-1 and Hsp70 and the formation of 4-hydroxy-2-nonenal (4HNE) adducts.
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18686200 Scharf B, Trombetta LD: Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of Long-Evans rats. J Toxicol Environ Health A. 2008;71(19):1300-6.

CDDC was recently introduced as an alternative to chromated copper arsenate (CCA) preserved wood.
Western blot analysis revealed the induction of the stress protein Hsp70 and the formation of 4-hydroxy-2-nonenal (4HNE) adducts in liver and renal tissues, indicating peroxidative damage.
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