Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name anabasine
CAS

Reference List

PubMed Abstract RScore(About this table)
2003276 Karadsheh N, Kussie P, Linthicum DS: Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives. Toxicol Lett. 1991 Mar;55(3):335-42.
163(2,2,2,3) Details
9084060 Tani Y, Saito K, Tsuneyoshi A, Imoto M, Ohno T: Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice. Psychopharmacology. 1997 Feb;129(3):225-32.

The changes in the monoamine turnover induced by (+/-)-anabasine were similar to those induced by (-)-nicotine, while (-)-lobeline and (-)-cytisine had little effect, and 1,1-dimethyl-4-phenyl-piperazinium (DMPP) increased NA and 5-HT turnover but not DA turnover at all doses tested. (S)-3-Methyl-5-(l-methyl-2- pyrrolidinyl) isoxazole (ABT-418), a selective neuronal nACh-R agonist, increased NA, DA and 5-HT turnover, but had a weaker effect on DA turnover than NA and 5-HT turnover.
In addition, 9-amino-1,2,3,4-tetrahydroacridine (THA), an acetylcholine esterase inhibitor, also increased monoamine turnover in the brain.
1(0,0,0,1) Details
12587870 Foster SP, Denholm I, Thompson R: Variation in response to neonicotinoid insecticides in peach-potato aphids, Myzus persicae (Hemiptera: Aphididae). Pest Manag Sci. 2003 Feb;59(2):166-73.


Laboratory bioassays applying the neonicotinoid insecticides imidacloprid, acetamiprid and nitenpyram against clones of the peach-potato aphid Myzus persicae (Sulzer) demonstrated that these compounds effectively circumvent the known carboxylesterase, modified acetylcholinesterase (MACE) and knock-down (kdr) insecticide resistance mechanisms in this species.
1(0,0,0,1) Details
720202 Dalimov DN, Abduvakhabov AA, Aslanov KhA, Sadykov AS, Mikhailov SS: [Reaction of N-[beta-(dialkoxyphosphinyl)-mercaptoethyl] anabasines and their diiodomethylates with human erythrocyte acetylcholinesterase and horse serum butyrylcholinesterase] Dokl Akad Nauk SSSR. 1978;243(1):240-3.

1(0,0,0,1) Details