Protein Information

Name IL 1a
Synonyms Hematopoietin 1; IL 1 alpha; IL 1A; IL1; IL1 alpha; IL1A; IL1F1; Interleukin 1 alpha…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19626424 Kondo Y, Tachikawa E, Ohtake S, Kudo K, Mizuma K, Kashimoto T, Irie Y, Taira E: Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation. Mol Cell Biochem. 2010 Jan;333(1-2):57-64. Epub 2009 Jul 22.

Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha.
81(1,1,1,1) Details
19637760 Didilescu AC, Hanganu SC, Galie N, Greabu M, Totan A, Stratul SI, Puiu L: [The role of smoking in changing essential parameters in body homeostasis] . Pneumologia. 2009 Apr-Jun;58(2):89-94.

Many studies suggest that nicotine induces vasoconstriction, not only in coronary arteries but also in peripheral vessels, hypertension, pro-atherogenic effects, due to increase of platelet activation and fatty acids concentration, alterations of endothelial-cell shapes, as well as endothelial-cell proliferation.
These effects are induced by alterations of endothelin-1, nitric oxide, IL1, IL6, TNF, and the CYP Enzyme System.
1(0,0,0,1) Details