| Name | FAAH |
|---|---|
| Synonyms | Anandamide amidohydrolase; FAAH; Fatty acid amide hydrolase; Oleamide hydrolase; Oleamide hydrolase Anandamide amidohydrolase FAAH; Fatty acid amide hydrolases; Oleamide hydrolases; Oleamide hydrolase Anandamide amidohydrolase FAAHs |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19484221 | Forget B, Coen KM, Le Foll B: Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB (1) receptor blockade. Psychopharmacology. 2009 Sep;205(4):613-24. Epub 2009 May 30. OBJECTIVE: The aim of the study was to explore the effect of inhibiting FAAH enzyme by URB597 on nicotine self-administration under a progressive ratio schedule and reinstatement of nicotine seeking, in comparison with the effect of the CB (1) antagonist rimonabant. |
114(1,2,2,4) | Details |
| 19239915 | Parker LA, Limebeer CL, Rock EM, Litt DL, Kwiatkowska M, Piomelli D: The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew). Physiol Behav. 2009 Apr 20;97(1):121-4. Epub 2009 Feb 23. |
63(0,2,2,3) | Details |
| 19091987 | Melis M, Pillolla G, Luchicchi A, Muntoni AL, Yasar S, Goldberg SR, Pistis M: Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic neurons through nuclear receptors. J Neurosci. 2008 Dec 17;28(51):13985-94. We discovered that pharmacological inhibition of fatty acid amide hydrolase (FAAH), the enzyme that catabolizes fatty acid ethanolamides, among which the endocannabinoid (AEA) is the best known, suppressed nicotine-induced excitation of cells. |
31(0,1,1,1) | Details |
| 20353771 | Hansen HS: Palmitoylethanolamide and other congeners. Exp Neurol. 2010 Mar 27. Inhibitors of the acylethanolamide-degrading enzyme FAAH can increase levels of all acylethanolamides including annandamide, and some of the pharmacological effects caused by these inhibitors may be explained by increased cerebral levels of OEA and PEA, e.g. suppression of nicotine-induced activation of neurons. |
31(0,1,1,1) | Details |
| 19470387 | Vann RE, Warner JA, Bushell K, Huffman JW, Martin BR, Wiley JL: Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice. Eur J Pharmacol. 2009 Aug 1;615(1-3):102-7. Epub 2009 May 23. As expected, nicotine failed to substitute for THC. |
0(0,0,0,0) | Details |