Protein Information

Name glutamate receptors (protein family or complex)
Synonyms Glutamate receptor; Glutamate receptors

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19145339 Gmiro VE, Serdyuk SE, Efremov OM: Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice. Bull Exp Biol Med. 2008 Jul;146(1):18-21.

High anticonvulsant activity of IEM-1460 on the model of nicotine-induced seizures is associated with combined blockade of nicotinic receptors (alpha3beta4 receptors) and glutamate receptors (GluR1 AMPA receptors).
81(1,1,1,1) Details
19464268 Placzek AN, Zhang TA, Dani JA: Age dependent nicotinic influences over dopamine neuron synaptic plasticity. Biochem Pharmacol. 2009 Oct 1;78(7):686-92. Epub 2009 May 21.

A single, acute exposure to addictive drugs, including nicotine, produces long-term potentiation (LTP) that can be quantified by measuring the shift in the subtypes of ionotropic glutamate receptors mediating evoked synaptic transmission.
6(0,0,1,1) Details
20021449 Bird MK, Lawrence AJ: Group I metabotropic glutamate receptors: involvement in drug-seeking and drug-induced plasticity. Curr Mol Pharmacol. 2009 Jan;2(1):83-94.

3(0,0,0,3) Details
19109494 Lamotte d'Incamps B, Ascher P: Four excitatory postsynaptic ionotropic receptors coactivated at the motoneuron-Renshaw cell synapse. J Neurosci. 2008 Dec 24;28(52):14121-31.


We found that the RC synaptic current involves four components of similar amplitudes mediated by two nicotinic receptors (nAChRs, tentatively identified as alpha (7) homomers and alpha (4) beta (2) heteromers) and two glutamate receptors (AMPARs and NMDARs).
1(0,0,0,1) Details