| Name | 5 HT 2C |
|---|---|
| Synonyms | 5 HT 2C; 5 HT2C; 5 HTR2C; 5 hydroxytryptamine (serotonin) receptor 2C; 5 hydroxytryptamine 2C receptor; 5 hydroxytryptamine receptor 2C; 5HT 1C; HTR1C… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19347958 | Zaniewska M, McCreary AC, Filip M: Interactions of serotonin (5-HT) 2 receptor-targeting ligands and nicotine: locomotor activity studies in rats. Synapse. 2009 Aug;63(8):653-61. Male Wistar rats were used to verify the hypothesis that (5-HT)(2A) or 5-HT (2C) receptors may control the locomotor effects evoked by nicotine (0.4 mg/kg). |
244(3,3,3,4) | Details |
| 20196140 | Zaniewska M, McCreary AC, Wydra K, Filip M: Differential effects of (5-HT)(2) receptor-targeting ligands on locomotor responses to nicotine-repeated treatment. Synapse. 2010 Mar 1;64(7):511-519. We verified the hypothesis that (5-HT)(2) receptors control the locomotor effects of nicotine (0.4 mg kg (-1)) in rats by using the 5-HT (2A) receptor antagonist M100907, the preferential 5-HT (2A) receptor agonist DOI, the 5-HT (2C) receptor antagonist SB 242084, and the 5-HT (2C) receptor agonists Ro 60-0175 and WAY 163909. |
31(0,1,1,1) | Details |
| 20153341 | Zaniewska M, McCreary AC, Wydra K, Filip M: Effects of (5-HT)(2) receptor ligands on depression-like behavior during nicotine withdrawal. Neuropharmacology. 2010 Feb 11. This data set demonstrates that 5-HT (2A) receptor antagonist and 5-HT (2C) receptor agonists exhibited effects similar to antidepressant drugs and abolished the depression-like effects in nicotine-withdrawn rats. |
31(0,1,1,1) | Details |
| 20060656 | Iordanidou M, Tavridou A, Petridis I, Kyroglou S, Kaklamanis L, Christakidis D, Manolopoulos VG: Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians. Drug Alcohol Depend. 2010 Apr 1;108(1-2):70-6. Epub 2010 Jan 8. BACKGROUND: The serotonergic system may be implicated in susceptibility to nicotine dependence as nicotine increases release in brain and symptoms of nicotine withdrawal may be modulated by diminished serotonergic neurotransmission. METHODS: 5-HTTLPR polymorphism of the 5-HT transporter gene and -759C/T (rs3813929) and -697G/C (rs518147) polymorphisms of the 5-HT (2C) receptor gene were analyzed in 172 smoking initiators and 254 non-initiators, using PCR-RFLP method. |
3(0,0,0,3) | Details |