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Patil AJ, Gramajo AL, Sharma A, Seigel GM, Kuppermann BD, Kenney MC: Differential effects of nicotine on retinal and vascular cells in vitro. Toxicology. 2009 May 2;259(1-2):69-76. Epub 2009 Feb 20.
In R28 cells, the nicotine effects were through an oxidant pathway that is non-caspase, non-calpain mediated while the HMVEC toxicity was via necrosis. |
31(0,1,1,1) |
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| 20132834 |
Garcia-Rates S, Camarasa J, Sanchez-Garcia AI, Gandia L, Escubedo E, Pubill D: The effects of 3,4-methylenedioxymethamphetamine (MDMA) on nicotinic receptors: Intracellular calcium increase, calpain/caspase 3 activation, and functional upregulation. Toxicol Appl Pharmacol. 2010 Feb 2.
It also concentration-dependently inhibited the response induced by ACh, nicotine, and the specific alpha7 agonist PNU 282987 with IC (50) values in the low micromolar range. |
4(0,0,0,4) |
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