Protein Information

Name UBA52
Synonyms HMG20; RPS27A; UBA80; UBCEP 1; UBCEP1; UBA52; UBCEP 2; UBCEP2…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19540050 Chapman MA: Does smoking reduce the risk of Parkinson's disease through stimulation of the ubiquitin-proteasome system?. Med Hypotheses. 2009 Dec;73(6):887-91. Epub 2009 Jun 18.

This hypothesis is supported by evidence documenting the upregulation of nicotinic receptors in the brains of smokers, neuroprotective effects of nicotine, reduced activity of the ubiquitin-proteasome in Parkinson's disease, and increased activity of the ubiquitin-proteasome system in animals exposed to chronic nicotine.
87(1,1,1,7) Details
19038236 Prokopczyk B, Sinha I, Trushin N, Freeman WM, El-Bayoumy K: Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chem Biol Interact. 2009 Feb 12;177(3):173-80. Epub 2008 Nov 6.

Genes identified are categorized as immune response (LTB4R), RNA surveillance pathway (SMG1), metabolism (ALDH7A1), genes frequently expressed in later stages of neoplastic development (MT1F), DNA binding (HIST3H3 and CHD1L), and protein biosynthesis (UBA52).
1(0,0,0,1) Details