| Name | mitogen activated protein kinase (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19729077 | Jeong GS, Lee SH, Jeong SN, Kim YC, Kim EC: Anti-inflammatory effects of on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. Int Immunopharmacol. 2009 Nov;9(12):1374-80. Epub 2009 Sep 1. MATERIALS AND METHODS: Western blotting was used to examine the effect of (10-40 microM) on the LPS- and nicotine-induced expression of cyclooxygenase-2 (COX-2), inducible synthase (iNOS), and heme oxygenase-1 (HO-1), as well as the phosphorylation of mitogen-activated protein kinases (MAPKs), in hPDL cells. |
81(1,1,1,1) | Details |
| 20211606 | Gubbins EJ, Gopalakrishnan M, Li J: alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells. Brain Res. 2010 Mar 6. Robust concentration-dependent increase in ERK1/2 phosphorylation was triggered by structurally diverse alpha7 nAChR agonists such as nicotine, GTS-21, SSR-180711A and PNU-282987 in the presence of the positive allosteric modulator (PAM) PNU-120596. ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin-dependent protein kinase II (CaMKII), p38 MAP kinase and mitogen-activated protein kinase kinase1/2 (MEK1/2), indicating the involvement of these kinases upstream of ERK1/2. |
3(0,0,0,3) | Details |
| 19139119 | Sun X, Ritzenthaler JD, Zheng Y, Roman J, Han S: inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009 Jan;8(1):110-8. We and others have shown previously that nicotine, a major component of tobacco, stimulates non-small cell lung carcinoma (NSCLC) proliferation through nicotinic acetylcholine receptor (nAChR)-mediated signals. The inhibitory effect of on alpha4 nAChR expression was accompanied by phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 and down-regulation of Akt phosphorylation. |
2(0,0,0,2) | Details |
| 20338106 | Shen T, Le W, Yee A, Kamdar O, Hwang PH, Upadhyay D: Nicotine induces resistance to chemotherapy in nasal epithelial cancer. . Am J Rhinol Allergy. 2010 Mar;24(2):e73-7. Furthermore, nicotine induced activation of AKT and MAPK pathways, while inhibition of MAPK using U0126 and AKT by phosphatidylinositol 3-kinase inhibitor, LY294002, in part, blocked the antiapoptotic effects of nicotine against cisplatin and etoposide-induced apoptosis in NC. |
163(2,2,2,3) | Details |
| 19358273 | Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA: Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer. 2009 Jul 15;125(2):276-85. Further, the kinase inhibitor inhibited the nicotine-mediated induction of OPN, suggesting that mitogen activated protein kinase signaling mechanism is involved. |
81(1,1,1,1) | Details |
| 19077124 | Welsby PJ, Rowan MJ, Anwyl R: Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. Eur J Neurosci. 2009 Jan;29(1):65-75. Epub 2008 Dec 11. Chronic nicotine enhancement of LTP was found to be dependent on PKA, ERK and Src kinases. |
0(0,0,0,0) | Details |
| 19247191 | Hu CZ, Cao YL, Huo HY, Zhao WH, Hu J: Inhibitory effect of ghrelin on nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells. J Cardiovasc Pharmacol. 2009 Mar;53(3):241-5. We also found that ghrelin inhibited nicotine-induced PKC, p38 MAPK, and NF-kappaB activation. |
68(0,2,3,3) | Details |
| 19293145 | Buckingham SD, Jones AK, Brown LA, Sattelle DB: Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacol Rev. 2009 Mar;61(1):39-61. Epub 2009 Mar 16. Abeta peptides and nicotine differentially activate several intracellular signaling pathways, including the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog pathway, the extracellular signal-regulated kinase/mitogen-activated protein kinase, and JAK-2/STAT-3 pathways. |
31(0,1,1,1) | Details |
| 19436652 | Vikman P, Xu CB, Edvinsson L: Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag. 2009;5(1):333-41. Epub 2009 Apr 8. METHODS: (DMSO)-soluble (lipid-soluble) cigarette smoking particles (DSP) were extracted from cigarette smoke (0.8 mg nicotine per cigarette; Marlboro). In addition, the activity of three mitogen-activated protein kinases (p38, ERK 1/2 and SAPK/JNK) and their downstream transcription factors (ATF-2, Elk-1 and c-Jun) were examined. |
3(0,0,0,3) | Details |
| 19280689 | Goettsch C, Goettsch W, Muller G, Seebach J, Schnittler HJ, Morawietz H: Nox4 overexpression activates reactive species and p38 MAPK in human endothelial cells. Biochem Biophys Res Commun. 2009 Mar 6;380(2):355-60. Nicotine dinucleotide oxidase (Nox) complexes are the main sources of reactive species (ROS) formation in the vessel wall. |
3(0,0,0,3) | Details |
| 19364472 | Goettsch C, Goettsch W, Muller G, Seebach J, Schnittler HJ, Morawietz H: Nox4 overexpression activates reactive species and p38 MAPK in human endothelial cells. Biochem Biophys Res Commun. 2009 Jan 23. Nicotine dinucleotide oxidase (Nox) complexes are the main sources of reactive species (ROS) formation in the vessel wall. |
3(0,0,0,3) | Details |
| 19753305 | Yu J, Huang NF, Wilson KD, Velotta JB, Huang M, Li Z, Lee A, Robbins RC, Cooke JP, Wu JC: nAChRs mediate human embryonic stem cell-derived endothelial cells: proliferation, apoptosis, and angiogenesis. PLoS One. 2009 Sep 15;4(9):e7040. Finally, in vitro mechanistic analysis suggests activation of the MAPK and Akt pathways following activation of nicotinic acetylcholine receptors (nAChRs). We tested the effect of nicotine (a key component of cigarette smoking) on the therapeutic effects of human embryonic stem cell-derived endothelial cells (hESC-ECs). |
2(0,0,0,2) | Details |