| Name | CD11b |
|---|---|
| Synonyms | CD11B; CD11b; CD11b antigen; CR 3 alpha chain; CR3A; Cell surface glycoprotein MAC 1 alpha subunit; ITGAM; Integrin alpha M beta 2… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19542466 | Huston JM, Rosas-Ballina M, Xue X, Dowling O, Ochani K, Ochani M, Yeboah MM, Chatterjee PK, Tracey KJ, Metz CN: Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b. J Immunol. 2009 Jul 1;183(1):552-9. Administration of nicotine, a pharmacologic agonist of the cholinergic anti-inflammatory pathway, significantly reduces levels of CD11b, a beta (2)-integrin involved in cell adhesion and leukocyte chemotaxis, on the surface of neutrophils in a dose-dependent manner and this function requires the spleen. |
164(2,2,2,4) | Details |
| 19155522 | Shi FD, Piao WH, Kuo YP, Campagnolo DI, Vollmer TL, Lukas RJ: Nicotinic attenuation of central nervous system inflammation and autoimmunity. J Immunol. 2009 Feb 1;182(3):1730-9. In the CNS, nicotine exposure selectively reduces numbers of CD11c (+) dendritic and CD11b (+) infiltrating monocytes and resident microglial cells and down-regulates the expression of MHC class II, CD80, and CD86 molecules on these cells. |
81(1,1,1,1) | Details |
| 19846875 | Nizri E, Irony-Tur-Sinai M, Lory O, Orr-Urtreger A, Lavi E, Brenner T: Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J Immunol. 2009 Nov 15;183(10):6681-8. Epub 2009 Oct 21. Accordingly, CD4 (+) and CD11b (+) cells infiltration into the CNS, demyelination, and axonal loss were reduced. |
1(0,0,0,1) | Details |