Protein Information

Name angiotensin II
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19063868 Marrero MB, Bencherif M: Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB. Brain Res. 2009 Feb 23;1256:1-7. Epub 2008 Nov 27.

Our laboratories have previously identified the alpha7 nAChR-JAK2 pathway as playing a central role in nicotine-induced neuroprotection.
We have also reported that the angiotensin II (Ang II) AT (2) receptor induced activation of SHP-1 induces the tyrosine dephosphorylation of JAK2 that results in a complete neutralization of the alpha7 nAChR-JAK2 pro-survival cascade.
1(0,0,0,1) Details
19429393 Mao C, Wu J, Xiao D, Lv J, Ding Y, Xu Z, Zhang L: The effect of fetal and neonatal nicotine exposure on renal development of AT (1) and AT (2) receptors. Reprod Toxicol. 2009 Apr;27(2):149-54. Epub 2009 Feb 11.

CONCLUSIONS: The results demonstrated that the development of renal angiotensin II receptor could be changed following exposure to perinatal nicotine, and such change in the kidney could be long-term in postnatal life.
112(1,2,2,2) Details