Protein Information

Name tight junction protein ZO 1
Synonyms TJP 1; TJP1; Tight junction protein 1; Tight junction protein 1 isoform a; Tight junction protein ZO 1; ZO 1; ZO1; Zona occludens 1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19841737 Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S: Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One. 2009 Oct 20;4(10):e7524.

In addition, nicotine significantly reduced the expression of epithelial markers, E-Cadherin and beta-Catenin as well as the tight junction protein ZO-1; these tumors also showed an increased expression of the alpha (7) nAChR subunit.
81(1,1,1,1) Details