| 19654299 |
Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S: Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res. 2009 Aug 15;69(16):6445-53. Epub 2009 Aug 4.
Of note, nicotine induced complex formation between alpha7 nAChR and PPARbeta/delta protein and increased PPARbeta/delta gene promoter activity through inhibition of AP-2alpha as shown by reduced AP-2alpha binding using electrophoretic gel mobility shift and chromatin immunoprecipitation assays. |
187(1,4,6,7) |
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