Protein Information

Name TRPA1
Synonyms ANKTM 1; ANKTM1; Ankyrin like protein with transmembrane domains 1; Ankyrin like with transmembrane domains protein 1; TRPA 1; TRPA1; Transformation sensitive protein p120; Transient receptor potential cation channel subfamily A member 1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19749751 Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, Everaerts W, Benoit M, Janssens A, Vennekens R, Viana F, Nemery B, Nilius B, Voets T: Nicotine activates the chemosensory cation channel TRPA1. . Nat Neurosci. 2009 Oct;12(10):1293-9. Epub 2009 Sep 13.
386(4,6,6,6) Details
19421772 Xiao R, Xu XZ: Function and regulation of TRP family channels in C. elegans. Pflugers Arch. 2009 Sep;458(5):851-60. Epub 2009 May 8.

For example, the TRPC channels TRP-1 and TRP-2 control nicotine-dependent behavior, while TRP-3, a sperm TRPC channel, is regulated by sperm activation and required for sperm-egg interactions during fertilization.
For instance, the TRPV channels OSM-9 and OCR-2 act in chemosensation, osmosensation, and touch sensation, the TRPA member TRPA-1 regulates touch sensation, while the TRPN channel TRP-4 mediates proprioception.
1(0,0,0,1) Details