| Name | PI3K |
|---|---|
| Synonyms | GRB 1; PI3K; GRB1; PI3 kinase p85 subunit alpha; Phosphatidyl inositol 3 kinase associated p85 alpha; Phosphatidylinositol 3 kinase regulatory subunit alpha; PtdIns 3 kinase p85 alpha… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19499400 | Junhui Z, Xiaojing H, Binquan Z, Xudong X, Junzhu C, Guosheng F: Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway. Cytotherapy. 2009;11(4):485-91. |
199(2,3,4,4) | Details |
| 19654299 | Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S: Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res. 2009 Aug 15;69(16):6445-53. Epub 2009 Aug 4. |
193(2,3,3,3) | Details |
| 19962381 | Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T: an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. J Mol Cell Cardiol. 2010 Apr;48(4):680-93. Epub 2009 Dec 3. Our recent studies have indicated that protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion. and nicotine upregulated signal transduction with acceleration of tube formation, suggesting that promotes a common angiogenesis pathway. |
1(0,0,0,1) | Details |
| 19714494 | Akaike A, Takada-Takatori Y, Kume T, Izumi Y: Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci. 2010 Jan;40(1-2):211-6. These results suggest that nicotine as well as AChE inhibitors, and galantamine, prevent neurotoxicity through alpha4 and alpha7 nAChRs and the PI3K-Akt pathway. |
83(1,1,1,3) | Details |
| 19252273 | Shimohama S: Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. Biol Pharm Bull. 2009 Mar;32(3):332-6. Nicotine-induced protection was blocked by an alpha7 nAChR antagonist, a phosphatidylinositol 3-kinase (PI3K) inhibitor, and an Src inhibitor. |
63(0,2,2,3) | Details |