Protein Information

Name interleukin (protein family or complex)
Synonyms Interleukin; Interleukins; interleukin receptor; interleukin receptors

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19890701 Li T, Zuo X, Zhou Y, Wang Y, Zhuang H, Zhang L, Zhang H, Xiao X: The vagus nerve and nicotinic receptors involve inhibition of HMGB1 release and early pro-inflammatory cytokines function in collagen-induced arthritis. J Clin Immunol. 2010 Mar;30(2):213-20. Epub 2009 Nov 5.

METHODS: Fifty-six male DBA/1 mice were divided into four groups: control mice (sham vagotomy + phosphate-buffered saline; shamVGX+PBS), model mice (shamVGX+PBS+CIA), vagotomy mice (VGX+PBS+CIA), and nicotine (Nic) mice (shamVGX+Nic+CIA).
The concentration of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-10 in serum were evaluated by ELISA.
1(0,0,0,1) Details
20337880 Johnson GK, Guthmiller JM, Joly S, Organ CC, Dawson DV: Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures. J Periodontal Res. 2010 Mar 9.

The objective of this study was to evaluate the effect of nicotine and bacterial lipopolysaccharide (LPS) alone and in combination on gingival keratinocyte production of interleukin-1alpha (IL-1alpha) and interleukin-8 (IL-8).
82(1,1,1,2) Details
19673871 Tsutakawa S, Kobayashi D, Kusama M, Moriya T, Nakahata N: Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model. Br J Dermatol. 2009 Nov;161(5):1020-7. Epub 2009 Jun 11.

To clarify the mechanism of the effect of nicotine, mRNA levels of cyclooxygenase-2 (COX-2), interleukin (IL)-1beta, IL-6 and inducible nitric oxide synthase (iNOS) and protein expression of COX-2 and iNOS in the necrotic area were investigated by real-time reverse transcription-polymerase chain reaction and Western blotting, respectively.
31(0,1,1,1) Details
19438974 Mahanonda R, Sa-Ard-Iam N, Eksomtramate M, Rerkyen P, Phairat B, Schaecher KE, Fukuda MM, Pichyangkul S: Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells. J Periodontal Res. 2009 Aug;44(4):557-64. Epub 2009 Mar 13.

The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay.
31(0,1,1,1) Details
20336357 Boland C, Collet V, Laterre E, Lecuivre C, Wittebole X, Laterre PF: Electrical Vagus Nerve Stimulation and Nicotine Effects in Peritonitis-Induced Acute Lung Injury in Rats. Inflammation. 2010 Mar 25.

Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-10, cytokine-induced neutrophil chemoattractant (CINC)-3 and thrombin-antithrombin complexes (TATc) were measured at baseline and at 4 and 8 h after CLP.
1(0,0,0,1) Details
19769802 Wang JH, Kim H, Jang YJ: Cigarette smoke extract enhances rhinovirus-induced toll-like receptor 3 expression and interleukin-8 secretion in A549 cells. Am J Rhinol Allergy. 2009 Nov-Dec;23(6):e5-9. Epub 2009 Sep 18.

BACKGROUND: Using A549 alveolar epithelial type II-like cells, we investigated the effects of cigarette smoke on the expression of rhinovirus (RV)-induced Toll-like receptor (TLR) 3, interleukin (IL)-6, and IL-8 secretion and viral replication.
METHODS: Cigarette smoke extract (CSE) was prepared by smoking two commercial cigarettes with filters (0.9-mg of nicotine and 8.5-mg of tar per cigarette).
1(0,0,0,1) Details