| Name | orexin |
|---|---|
| Synonyms | HCRT; PPOX; Hcrt; Hypocretin; Hypocretin neuropeptide; OX; Orexin; Orexin precursor… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20147556 | Plaza-Zabala A, Martin-Garcia E, de Lecea L, Maldonado R, Berrendero F: Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. J Neurosci. 2010 Feb 10;30(6):2300-10. Therefore, the Hcrt system interacts with CRF and AVP neurons in the PVN and modulates the anxiogenic-like effects of nicotine whereas Hcrt and CRF play a different role in the reinstatement of nicotine-seeking. |
80(0,2,5,5) | Details |
| 19828259 | von der Goltz C, Koopmann A, Dinter C, Richter A, Rockenbach C, Grosshans M, Nakovics H, Wiedemann K, Mann K, Winterer G, Kiefer F: Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward. Psychoneuroendocrinology. 2010 May;35(4):570-7. Epub 2009 Oct 13. |
70(0,2,3,5) | Details |
| 19596018 | Winrow CJ, Tanis KQ, Reiss DR, Rigby AM, Uslaner JM, Uebele VN, Doran SM, Fox SV, Garson SL, Gotter AL, Levine DM, Roecker AJ, Coleman PJ, Koblan KS, Renger JJ: Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology. 2010 Jan;58(1):185-94. Epub 2009 Jul 14. Orexin is a key neurotransmitter of central arousal and reward circuits in the CNS. Further, DORA attenuates the ability of nicotine to induce reinstatement of extinguished responding for a reinforcer, demonstrating selectivity of the effect to reward pathways and not to food intake. |
4(0,0,0,4) | Details |
| 20236223 | Pasumarthi RK, Fadel J: Stimulation of lateral hypothalamic and efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. J Neurochem. 2010 Mar 4. |
230(2,4,5,5) | Details |
| 19033203 | Hollander JA, Lu Q, Cameron MD, Kamenecka TM, Kenny PJ: Insular hypocretin transmission regulates nicotine reward. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19480-5. Epub 2008 Nov 24. Blockade of Hcrt-1 receptors also abolished the stimulatory effects of nicotine on brain reward circuitries, as measured by reversal of nicotine-induced lowering of intracranial self-stimulation thresholds. |
155(1,3,5,5) | Details |
| 20177882 | LeSage MG, Perry JL, Kotz CM, Shelley D, Corrigall WA: Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. Psychopharmacology. 2010 Apr;209(2):203-12. Epub 2010 Feb 24. |
113(1,2,2,3) | Details |
| 19529922 | Corrigall WA: Hypocretin mechanisms in nicotine addiction: evidence and speculation. Psychopharmacology. 2009 Sep;206(1):23-37. Epub 2009 Jun 16. Theoretically, hypocretin (hcrt) mechanisms appear to be potential substrates for nicotine addiction: arousal and attentional mechanisms influence use and withdrawal symptoms, and hcrt systems overlap anatomically with a number of brain regions associated with nicotine addiction. |
88(1,1,2,3) | Details |