| Name | CD86 molecules |
|---|---|
| Synonyms | Activation B7 2 antigen; B lymphocyte activation antigen B7 2; B7 2; B70; BU63; CD28 antigen ligand 2; CD28LG2; CD86… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19155522 | Shi FD, Piao WH, Kuo YP, Campagnolo DI, Vollmer TL, Lukas RJ: Nicotinic attenuation of central nervous system inflammation and autoimmunity. J Immunol. 2009 Feb 1;182(3):1730-9. In the CNS, nicotine exposure selectively reduces numbers of CD11c (+) dendritic and CD11b (+) infiltrating monocytes and resident microglial cells and down-regulates the expression of MHC class II, CD80, and CD86 molecules on these cells. |
81(1,1,1,1) | Details |
| 19626424 | Kondo Y, Tachikawa E, Ohtake S, Kudo K, Mizuma K, Kashimoto T, Irie Y, Taira E: Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation. Mol Cell Biochem. 2010 Jan;333(1-2):57-64. Epub 2009 Jul 22. We showed that stimulation of the JawsII cells with lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF-alpha) led increase of CD80 and CD86 expression while diminishment of the surface nicotinic receptor. Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha. |
1(0,0,0,1) | Details |