Protein Information

Name estrogen receptor
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19767877 El-Mas MM, El-Gowilly SM, Gohar EY, Ghazal AR: Sex and hormonal influences on the nicotine-induced attenuation of isoprenaline vasodilations in the perfused rat kidney. Can J Physiol Pharmacol. 2009 Jul;87(7):539-48.

Renal responses to isoprenaline together with the attenuation of these responses by nicotine were reduced by OVX and restored to near-proestrus levels after supplementation with estradiol, the estrogen receptor modulator tamoxifen, or l -arginine.
81(1,1,1,1) Details
19442878 Raval AP, Bhatt A, Saul I: Chronic nicotine exposure inhibits 17beta-estradiol-mediated protection of the hippocampal CA1 region against cerebral ischemia in female rats. Neurosci Lett. 2009 Jul 17;458(2):65-9. Epub 2009 Apr 14.

In the current study based on a rat model of global cerebral ischemia, our goals are (1) to determine whether chronic nicotine exposure abrogates beneficial effects of estrogen on hippocampal neurons subjected to ischemia, and (2) to determine whether nicotine exposure antagonizes estrogen signaling by reducing the availability of estrogen receptor (s).
81(1,1,1,1) Details
19281722 Bergert FW, Conrad D, Ehrenthal K, Fessler J, Gross J, Gundermann K, Kluthe B, Lang Heinrich W, Liesenfeld A, Loew PG, Luther E, Pchalek R, Seffrin J, Sterzing A, Wolfring HJ, Zimmermann U: Pharmacotherapy guidelines for the aged by family doctors for the use of family doctors: part C--Special pharmacology. Int J Clin Pharmacol Ther. 2009 Mar;47(3):141-52.

Exercise, adequate diet, nicotine abstinence as well as reduction of alcohol consumption may counteract the progression of the disease.
Specific osteoporosis medication e.g. calcium, vitamin D, biphosphonates and SERM (selective estrogen receptor modulators) is evaluated by family doctors according to indication, dosage, contraindications, long-term therapy and nature of any fracture.
1(0,0,0,1) Details