Protein Information

Name P12
Synonyms DNA polymerase II subunit 4; p12; DNA polymerase epsilon p12 subunit; DNA polymerase epsilon subunit 4; DNA polymerase epsilon subunit p12; POLE 4; POLE4; DNA polymerase epsilon p12 subunits…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19818418 Niane L, Joseph V, Bairam A: Role of cholinergic-nicotinic receptors on hypoxic chemoreflex during postnatal development in rats. Respir Physiol Neurobiol. 2009 Dec 31;169(3):323-32. Epub 2009 Oct 7.

In P12 rats, in vitro recordings of carotid sinus nerve activity showed that superfusion with nicotine enhanced chemosensory discharge rate in normoxia and hexamethonium reduced the discharge rate in hypoxia.
34(0,1,1,4) Details
19625996 Ishibashi M, Leonard CS, Kohlmeier KA: Nicotinic activation of laterodorsal tegmental neurons: implications for addiction to nicotine. Neuropsychopharmacology. 2009 Nov;34(12):2529-47. Epub 2009 Jul 22.

We addressed this issue by examining the effects of nicotine on identified cholinergic and non-cholinergic LDT neurons using whole-cell patch clamp and Ca (2+)-imaging methods in brain slices from mice (P12-P45).
6(0,0,1,1) Details