Protein Information

Name beta defensin 2
Synonyms BD 2; SAP1; Beta defensin 2; Beta defensin 2 precursor; DEFB 2; DEFB102; DEFB2; DEFB4…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19617917 Aldhous MC, Noble CL, Satsangi J: Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS One. 2009 Jul 20;4(7):e6285.

We investigated environmental and genetic influences on HBD2 protein production using ex vivo cultured sigmoid colon biopsies from 69 patients (22 CD, 26 UC, 21 controls) stimulated with lipopolysaccharide (LPS) and/or nicotine for 24 hours.
41(0,1,1,11) Details
19438974 Mahanonda R, Sa-Ard-Iam N, Eksomtramate M, Rerkyen P, Phairat B, Schaecher KE, Fukuda MM, Pichyangkul S: Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells. J Periodontal Res. 2009 Aug;44(4):557-64. Epub 2009 Mar 13.

The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay.
36(0,1,1,6) Details