| Name | catechol O methyltransferase |
|---|---|
| Synonyms | COMT; COMT protein; Catechol O methyltransferase; Catechol O methyltransferase isoform MB COMT; MB COMT; COMT proteins; Catechol O methyltransferases; Catechol O methyltransferase isoform MB COMTs |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19065145 | Loughead J, Wileyto EP, Valdez JN, Sanborn P, Tang K, Strasser AA, Ruparel K, Ray R, Gur RC, Lerman C: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Mol Psychiatry. 2009 Aug;14(8):820-6. Epub 2008 Dec 9. We tested the hypothesis that the val allele is a risk factor for altered brain function and cognition during nicotine abstinence as compared with the normal smoking state. |
5(0,0,0,5) | Details |
| 19584770 | Breitling LP, Dahmen N, Illig T, Rujescu D, Nitz B, Raum E, Winterer G, Rothenbacher D, Brenner H: Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. Pharmacogenet Genomics. 2009 Aug;19(8):657-9. |
2(0,0,0,2) | Details |
| 19940429 | Blum K, Chen TJ, Downs BW, Bowirrat A, Waite RL, Braverman ER, Madigan M, Oscar-Berman M, DiNubile N, Stice E, Giordano J, Morse S, Gold M: Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). Postgrad Med. 2009 Nov;121(6):176-96. PROPOSAL AND CONCLUSION: We propose that low D2 receptor density and polymorphisms of the D2 gene are associated with risk for relapse of substance abuse, including alcohol dependence, heroin craving, cocaine dependence, methamphetamine abuse, nicotine sensitization, and craving. This hypothesized mechanism is supported by clinical trials utilizing amino acid neurotransmitter precursors, enkephalinase, and catechol-O-methyltransferase (COMT) enzyme inhibition, which have resulted in attenuated relapse rates in reward deficiency syndrome (RDS) probands. |
2(0,0,0,2) | Details |
| 20102619 | McEachin RC, Saccone NL, Saccone SF, Kleyman-Smith YD, Kar T, Kare RK, Ade AS, Sartor MA, Cavalcoli JD, McInnis MG: Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder. BMC Med Genet. 2010 Jan 26;11:14. We found three candidate genes associated with both BD and TUD (COMT, SLC6A3, and SLC6A4) and commonality analysis suggests that these genes interact in predisposing psychiatric and substance use disorders. Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD. |
1(0,0,0,1) | Details |
| 19415821 | Tang X, Guo S, Sun H, Song X, Jiang Z, Sheng L, Zhou D, Hu Y, Chen D: Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. Pharmacogenet Genomics. 2009 May;19(5):345-52. OBJECTIVES: Nicotine is the major psychoactive ingredient in tobacco, and is responsible for dependence through the nicotine-stimulated reward pathway mediated by the central dopaminergic system. In this study, we investigated the association and multilocus gene-gene interactions of cytochrome P450 2A6 (CYP2A6), dopamine beta-hydroxylase (DBH), O-methyl transferase (COMT), and monoamine oxidase A (MAOA) polymorphisms with smoking behavior in a community-based Chinese male population. |
1(0,0,0,1) | Details |
| 19827313 | Kotyuk E, Kovacs-Nagy R, Faludi G, Urban R, Ronai Z, Sasvari-Szekely M, Szekely A: [Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression]. Neuropsychopharmacol Hung. 2009 Jun;11(2):59-67. Dimensional endophenotypes of nicotine addiction have been characterized by Hungarian adaptations of the Hooked on Nicotine Checklist and the Fagerstrom Test for Nicotine Dependence. Exon of the DRD4 (DRD4 VNTR), two promoter SNPs of this gene (-521 CT and -616CG), as well as the repeat polymorphism of the dopamine transporter (DAT VNTR) polymorphism and the Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene. |
1(0,0,0,1) | Details |
| 19693267 | Roe BE, Tilley MR, Gu HH, Beversdorf DQ, Sadee W, Haab TC, Papp AC: Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. PLoS One. 2009 Aug 20;4(8):e6704. |
0(0,0,0,0) | Details |
| 20188797 | Nedic G, Nikolac M, Borovecki F, Hajnsek S, Muck-Seler D, Pivac N: Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neurosci Lett. 2010 Apr 12;473(3):216-9. Epub 2010 Feb 25. |
5(0,0,0,5) | Details |
| 19014506 | Blum K, Chen AL, Chen TJ, Braverman ER, Reinking J, Blum SH, Cassel K, Downs BW, Waite RL, Williams L, Prihoda TJ, Kerner MM, Palomo T, Comings DE, Tung H, Rhoades P, Oscar-Berman M: Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theor Biol Med Model. 2008 Nov 12;5:24. Individuals possessing a paucity of serotonergic and/or dopaminergic receptors, and an increased rate of synaptic DA catabolism due to high catabolic genotype of the COMT gene, are predisposed to self-medicating any substance or behavior that will activate DA release, including opiates, psychostimulants, nicotine, gambling, sex, and even excessive internet gaming. |
31(0,1,1,1) | Details |