| Name | cyclooxygenase 2 |
|---|---|
| Synonyms | COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19147120 | Nakao S, Ogata Y, Sugiya H: Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts. Arch Oral Biol. 2009 Mar;54(3):251-7. Epub 2009 Jan 14. |
62(0,2,2,2) | Details |
| 19729077 | Jeong GS, Lee SH, Jeong SN, Kim YC, Kim EC: Anti-inflammatory effects of on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. Int Immunopharmacol. 2009 Nov;9(12):1374-80. Epub 2009 Sep 1. MATERIALS AND METHODS: Western blotting was used to examine the effect of (10-40 microM) on the LPS- and nicotine-induced expression of cyclooxygenase-2 (COX-2), inducible synthase (iNOS), and heme oxygenase-1 (HO-1), as well as the phosphorylation of mitogen-activated protein kinases (MAPKs), in hPDL cells. |
31(0,1,1,1) | Details |
| 20079464 | Zhou Y, Wang ZX, Tang MP, Yao CJ, Xu WJ, Wang LY, Qiao ZD: Nicotine induces cyclooxygenase-2 and (2) expression in human umbilical vein endothelial cells. Int Immunopharmacol. 2010 Apr;10(4):461-6. Epub 2010 Jan 14. In order to explain the mechanism of nicotine-induced endothelium dysfunction, we investigated the effects of nicotine on cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVECs). |
37(0,1,2,2) | Details |
| 19673871 | Tsutakawa S, Kobayashi D, Kusama M, Moriya T, Nakahata N: Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model. Br J Dermatol. 2009 Nov;161(5):1020-7. Epub 2009 Jun 11. To clarify the mechanism of the effect of nicotine, mRNA levels of cyclooxygenase-2 (COX-2), interleukin (IL)-1beta, IL-6 and inducible synthase (iNOS) and protein expression of COX-2 and iNOS in the necrotic area were investigated by real-time reverse transcription-polymerase chain reaction and Western blotting, respectively. |
31(0,1,1,1) | Details |
| 19955489 | Takahashi HK, Liu K, Wake H, Mori S, Zhang J, Liu R, Yoshino T, Nishibori M: Effect of nicotine on advanced glycation end product-induced immune response in human monocytes. J Pharmacol Exp Ther. 2010 Mar;332(3):1013-21. Epub 2009 Dec 2. Nicotine induced the expression of cyclooxygenase-2, (2) (PGE (2)), and cAMP in the presence and absence of AGE-2 and AGE-3. |
6(0,0,1,1) | Details |
| 19892012 | Lin CC, Lee IT, Yang YL, Lee CW, Kou YR, Yang CM: Induction of COX-2/PGE (2)/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent oxidase activation. Free Radic Biol Med. 2010 Jan 15;48(2):240-54. Epub 2009 Nov 3. In addition, treatment with nicotine could induce COX-2, PGE (2), and IL-6 generation in in vivo and in vitro studies. Cyclooxygenase-2 (COX-2) and (2) (PGE (2)) have been shown to play critical roles in respiratory inflammation. |
1(0,0,0,1) | Details |