Protein Information

Name calcium calmodulin dependent protein kinase II
Synonyms CAMK2N1; CaMKIINalpha; Calcium/calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II inhibitor alpha; ICAP 1alpha; PRO1489; RP11 401M16.1; RP11 401M16.1 001…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19435931 Jackson KJ, Walters CL, Damaj MI: Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. J Pharmacol Exp Ther. 2009 Aug;330(2):541-9. Epub 2009 May 12.
82(1,1,1,2) Details
19619563 Jackson KJ, Walters CL, Miles MF, Martin BR, Damaj MI: Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice. Neuropharmacology. 2009 Sep;57(4):347-55. Epub 2009 Jul 18.

In general, D2 mice were less sensitive than B6 mice to the acute effects of nicotine, but were more sensitive to blockade of nicotine-induced antinociceptive responses by a calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor.
31(0,1,1,1) Details
19336664 Jackson KJ, Damaj MI: L-type calcium channels and calcium/calmodulin-dependent kinase II differentially mediate behaviors associated with nicotine withdrawal in mice. J Pharmacol Exp Ther. 2009 Jul;330(1):152-61. Epub 2009 Mar 31.

Studies suggest a role for calcium-dependent mechanisms, such as L-type calcium channels and calcium/calmodulin-dependent protein kinase II (CaMKII), in the effects of nicotine dependence; however, the role of these mechanisms in nicotine-mediated behaviors is unclear.
31(0,1,1,1) Details