| Name | tumor necrosis factor |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19890701 | Li T, Zuo X, Zhou Y, Wang Y, Zhuang H, Zhang L, Zhang H, Xiao X: The vagus nerve and nicotinic receptors involve inhibition of HMGB1 release and early pro-inflammatory cytokines function in collagen-induced arthritis. J Clin Immunol. 2010 Mar;30(2):213-20. Epub 2009 Nov 5. METHODS: Fifty-six male DBA/1 mice were divided into four groups: control mice (sham vagotomy + -buffered saline; shamVGX+PBS), model mice (shamVGX+PBS+CIA), vagotomy mice (VGX+PBS+CIA), and nicotine (Nic) mice (shamVGX+Nic+CIA). The concentration of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-10 in serum were evaluated by ELISA. |
1(0,0,0,1) | Details |
| 19626424 | Kondo Y, Tachikawa E, Ohtake S, Kudo K, Mizuma K, Kashimoto T, Irie Y, Taira E: Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation. Mol Cell Biochem. 2010 Jan;333(1-2):57-64. Epub 2009 Jul 22. We showed that stimulation of the JawsII cells with lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF-alpha) led increase of CD80 and CD86 expression while diminishment of the surface nicotinic receptor. Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha. |
1(0,0,0,1) | Details |
| 19593403 | Rosas-Ballina M, Goldstein RS, Gallowitsch-Puerta M, Yang L, Valdes-Ferrer SI, Patel NB, Chavan S, Al-Abed Y, Yang H, Tracey KJ: The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med. 2009 Jul-Aug;15(7-8):195-202. Epub 2009 Apr 27. We report here our findings that GTS-21 attenuates tumor necrosis factor (TNF) and interleukin 1beta levels in human whole blood activated by exposure to endotoxin. The suppressive effect of GTS-21 was more potent than nicotine in whole blood and monocytes. |
1(0,0,0,1) | Details |
| 19729077 | Jeong GS, Lee SH, Jeong SN, Kim YC, Kim EC: Anti-inflammatory effects of on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. Int Immunopharmacol. 2009 Nov;9(12):1374-80. Epub 2009 Sep 1. Pro-inflammatory mediators, including (NO), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-12 were monitored using Griess reagents and ELISA. |
1(0,0,0,1) | Details |
| 19955489 | Takahashi HK, Liu K, Wake H, Mori S, Zhang J, Liu R, Yoshino T, Nishibori M: Effect of nicotine on advanced glycation end product-induced immune response in human monocytes. J Pharmacol Exp Ther. 2010 Mar;332(3):1013-21. Epub 2009 Dec 2. Among various subtypes of AGEs, -derived AGE (AGE-2) and -derived AGE (AGE-3) induce the expressions of intercellular adhesion molecule-1, B7.1, B7.2, and CD40 on monocytes, the production of interferon-gamma and tumor necrosis factor-alpha, and the lymphocyte proliferation in human peripheral blood mononuclear cells. |
1(0,0,0,1) | Details |
| 19116908 | van Maanen MA, Lebre MC, van der Poll T, LaRosa GJ, Elbaum D, Vervoordeldonk MJ, Tak PP: Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum. 2009 Jan;60(1):114-22. Moreover, oral nicotine inhibited bone degradation and reduced TNFalpha expression in synovial tissue. |
83(1,1,1,3) | Details |
| 19209239 | Mabley JG, Pacher P, Szabo C: Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice. Mol Med. 2009 May-Jun;15(5-6):166-72. Epub 2009 Feb 5. Nicotine administration 2 h after ricin injection significantly delayed and reduced ricin-induced mortality, an effect coupled with reduced serum levels of tumor necrosis factor-alpha and markers of kidney and liver dysfunction. |
82(1,1,1,2) | Details |
| 20336357 | Boland C, Collet V, Laterre E, Lecuivre C, Wittebole X, Laterre PF: Electrical Vagus Nerve Stimulation and Nicotine Effects in Peritonitis-Induced Acute Lung Injury in Rats. Inflammation. 2010 Mar 25. Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-10, cytokine-induced neutrophil chemoattractant (CINC)-3 and thrombin-antithrombin complexes (TATc) were measured at baseline and at 4 and 8 h after CLP. |
1(0,0,0,1) | Details |