Protein Information

Name RANKL
Synonyms CD254; ODF; SODF; CD254 antigen; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19602125 Ho YC, Yang SF, Huang FM, Chang YC: Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotine. J Periodontal Res. 2009 Dec;44(6):760-6. Epub 2009 Jul 8.

The aim of this study was to investigate the expression of interleukin-1, interleukin-8, receptor activator of nuclear factor-kappaB ligand (RANKL), gelatinases and tissue-type plasminogen activator in U2OS cells (from the human osteosarcoma cell line) stimulated with nicotine.
69(0,2,3,4) Details
19656028 Lee HJ, Pi SH, Kim Y, Kim HS, Kim SJ, Kim YS, Lee SK, Kim EC: Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells. J Periodontol. 2009 Aug;80(8):1281-8.

Pretreatment with antioxidants inhibited the upregulation of RANKL, the downregulation of OPG expression, and cytotoxicity by nicotine in PDL cells.
55(0,1,5,5) Details