Protein Information

Name Erk 5
Synonyms BMK 1; ERK4; BMK1; BMK1 kinase; ERK 5; ERK5; Extracellular signal regulated kinase 5; MAPK 7…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20061081 Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM, Cho CH: Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. Cancer Lett. 2010 Jan 8.

Thus, we conclude that the promotion effect of nicotine on cancer cell progression and EMT is mediated by Erk/5-LOX signaling pathway.
81(1,1,1,1) Details