| Name | CREB |
|---|---|
| Synonyms | Active transcription factor CREB; CREB; CREB 1; CREB1; cAMP response element binding protein; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1 isoform B… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19387337 | Al-Wadei HA, Al-Wadei MH, Schuller HM: Prevention of pancreatic cancer by the beta-blocker . Anticancer Drugs. 2009 Jul;20(6):477-82. We have previously reported that beta-adrenergic receptors (beta-ARs) stimulate the proliferation and migration of human PDAC cells in vitro by cAMP-dependent signaling and that the nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK) activates this pathway directly in vitro while additionally stimulating the release of / by binding to alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) in hamsters. |
0(0,0,0,0) | Details |
| 19077117 | Mineur YS, Brunzell DH, Grady SR, Lindstrom JM, McIntosh JM, Marks MJ, King SL, Picciotto MR: Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. Genes Brain Behav. 2009 Apr;8(3):257-66. Epub 2008 Dec 11. |
0(0,0,0,0) | Details |
| 20047710 | Lenz B, Klafki HW, Hillemacher T, Killisch N, Schaller G, Frieling H, Clepce M, Gossler A, Thuerauf N, Winterer G, Kornhuber J, Bleich S: Smoking behaviour is associated with expression and phosphorylation of CREB in human buffy coat. Int J Neuropsychopharmacol. 2010 Mar;13(2):207-15. Epub 2010 Jan 5. Nicotinic acetylcholine receptors (nAChRs) are involved in nicotine-induced phosphorylation of CREB (cyclic AMP response element-binding protein) in PC12h cells. |
86(1,1,1,6) | Details |
| 19212318 | Brunzell DH, Mineur YS, Neve RL, Picciotto MR: Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. Neuropsychopharmacology. 2009 Jul;34(8):1993-2001. Epub 2009 Feb 11. Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation. |
44(0,1,3,4) | Details |
| 19711055 | Pascual MM, Pastor V, Bernabeu RO: Nicotine-conditioned place preference induced CREB phosphorylation and Fos expression in the adult rat brain. Psychopharmacology. 2009 Nov;207(1):57-71. Epub 2009 Aug 27. |
31(0,1,1,1) | Details |
| 19830406 | El-Ghundi MB, Fan T, Karasinska JM, Yeung J, Zhou M, O'Dowd BF, George SR: Restoration of amphetamine-induced locomotor sensitization in D1 receptor-deficient mice. Psychopharmacology. 2010 Jan;207(4):599-618. Epub 2009 Oct 15. METHODS: D (1) (-/-) and wild-type (D (1) (+/+) ) mice pretreated with amphetamine (1 mg/kg, 3-7 days) or various doses of nicotine (chronically but intermittently) were challenged with amphetamine (0.7 and/or 1 mg/kg) after short and long abstinence periods. Expression of brain-derived neurotrophic factor (BDNF) and phosphorylated c-AMP response element binding protein (p-CREB) genes were measured under basal conditions and after acute or repeated amphetamine treatments. |
2(0,0,0,2) | Details |
| 20211606 | Gubbins EJ, Gopalakrishnan M, Li J: alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells. Brain Res. 2010 Mar 6. The present study examined activation of ERK1/2 and explored pathways leading to CREB phosphorylation utilizing alpha7 nAChR-selective ligands in PC12 cells endogenously expressing alpha7 nAChRs. Robust concentration-dependent increase in ERK1/2 phosphorylation was triggered by structurally diverse alpha7 nAChR agonists such as nicotine, GTS-21, SSR-180711A and PNU-282987 in the presence of the positive allosteric modulator (PAM) PNU-120596. |
2(0,0,0,2) | Details |
| 19435931 | Jackson KJ, Walters CL, Damaj MI: Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. J Pharmacol Exp Ther. 2009 Aug;330(2):541-9. Epub 2009 May 12. Substrates of this kinase include the vesicle-associated protein synapsin I and the transcription factor cAMP response element-binding protein (CREB). |
1(0,0,0,1) | Details |
| 19274673 | Al-Wadei HA, Schuller HM: Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. J Pathol. 2009 Aug;218(4):437-45. The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK) is a potent mutagen and the most powerful tobacco carcinogen. In contrast, protein expression of the alpha (7) nAChR, alpha (4) nAChR as well as p-CREB and p-ERK1/2 were up-regulated. |
1(0,0,0,1) | Details |