Protein Information

Name GABBR1
Synonyms GABA B R1; GABA B receptor; GABA B receptor 1; GABAB(1e); GABABR 1; GABABR1; GABBR 1; GABBR1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20175221 Naseer MI, Lee HY, Kim MO: Neuroprotective effect of vitamin C against the ethanol and nicotine modulation of GABA (B) receptor and PKA-alpha expression in prenatal rat brain. Synapse. 2010 Feb 19;64(6):467-477.
82(1,1,1,2) Details
20202080 Yu G, Chen H, Wu X, Matta SG, Sharp BM: Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress. J Neurochem. 2010 Feb 25.

Additionally, in rats self-administering nicotine, footshock-induced elevation of corticosterone was significantly less than in controls after intra-PVN saclofen (GABA-B receptor antagonist).
31(0,1,1,1) Details
19250803 Fattore L, Spano MS, Cossu G, Scherma M, Fratta W, Fadda P: Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents. Eur Neuropsychopharmacol. 2009 Jul;19(7):487-98. Epub 2009 Feb 28.

The gamma-aminobutyric acid (GABA)-B receptor agonist baclofen is known to reduce drug intake in both animals and humans and to prevent reinstatement of cocaine-, opioid-, and alcohol-seeking in rats after a period of extinction, but its effect on nicotine reinstatement is unknown.
31(0,1,1,1) Details
19763258 Li MD, Mangold JE, Seneviratne C, Chen GB, Ma JZ, Lou XY, Payne TJ: Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. PLoS One. 2009 Sep 18;4(9):e7055.

8(0,0,0,8) Details