Protein Information

Name neurotrophic factors
Synonyms ARTN; Artemin; Artemin precursor; EVN; Enovin; NBN; Neublastin; Neuroblastin…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20056136 Formaggio E, Fazzini F, Dalfini AC, Di Chio M, Cantu C, Decimo I, Fiorini Z, Fumagalli G, Chiamulera C: Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.

In this study, we investigated whether the potential positive effects of nicotine in Alzheimer's disease (AD) may involve neurotrophic factors, such as nerve growth factor (NGF), closely associated with basal forebrain (BF) cholinergic function and survival.
31(0,1,1,1) Details
19410565 Son JH, Winzer-Serhan UH: Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Res. 2009 Jun 30;1278:1-14. Epub 2009 May 3.
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19824047 Urrego F, Scuri M, Auais A, Mohtasham L, Piedimonte G: Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Pediatr Pulmonol. 2009 Nov;44(11):1075-84.

Previously, we have shown that infection with respiratory syncytial virus upregulates expression of neurotrophic factors and receptors in the lungs, but the effect of tobacco exposure on neurotrophins is unknown.
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19830843 Nai Q, Wang X, Jin Y, Sun D, Li M, Hu B, Zhang X: Ciliary neurotrophic factor enhances nicotinic synaptic transmission in sympathetic neurons. J Neurosci Res. 2010 Mar;88(4):887-95.


The findings of this study reinforce the rationale for the usage of combinations of different neurotrophic factors for the therapy of neurodegenerative diseases.
1(0,0,0,1) Details