Protein Information

Name beta site amyloid precursor protein cleaving enzyme
Synonyms ASP2; App beta secretase; Asp 2; Asp2; Aspartyl protease 2; BACE; BACE 1; BACE1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19464074 Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA: Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease. Neurobiol Aging. 2009 May 20.

The results indicate that 6 weeks of nicotine treatment reduced the levels of Abeta (1-40) and BACE1 peptides in hippocampal area CA1 and prevented Abeta-induced impairment of learning and short-term memory.
37(0,1,2,2) Details