| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19285975 | Yue J, Khokhar J, Miksys S, Tyndale RF: Differential induction of -metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary intake. Eur J Pharmacol. 2009 May 1;609(1-3):88-95. Epub 2009 Mar 13. |
95(1,1,3,5) | Details |
| 20233178 | Hukkanen J, Jacob Iii P, Peng M, Dempsey D, Benowitz NL: Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010 Feb;69(2):152-9. AIMS: Smoking slows the metabolism of nicotine and accelerates the metabolism of chlorzoxazone, which are probe reactions for cytochrome P450 2A6 (CYP2A6) and CYP2E1 activities, respectively. |
32(0,1,1,2) | Details |
| 19019380 | Petsalo A, Turpeinen M, Pelkonen O, Tolonen A: Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column. J Chromatogr A. 2008 Dec 26;1215(1-2):107-15. Epub 2008 Nov 7. CYP-specific metabolites of (CYP1A2), nicotine (CYP2A6), (CYP2B6), repaglinide (CYP2C8), losartan (CYP2C9), (CYP2C19 and CYP3A4), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4) were all analyzed using the same LC/MS/MS method with a single analytical run, either after a one-at-a-time dose or cocktail-type dosing of the parent drugs. |
31(0,1,1,1) | Details |
| 19107435 | Seitz HK, Cho CH: Contribution of and tobacco use in gastrointestinal cancer development. Methods Mol Biol. 2009;472:217-41. Smoking increases the burden following consumption and drinking enhances the activation of various procarcinogens present in tobacco smoke due to increased metabolic activation by an induced cytochrome P450-2E1-dependent microsomal biotransformation system in the mucosa of the upper digestive tract and the liver. Tobacco smoke contains a great number of mutagenic and carcinogenic compounds, including polycyclic carbohydrates, nitrosamines, and nicotine, while per se has only weak carcinogenic potential, but its first metabolite, is a mutagen and carcinogen, since it forms stable adducts with DNA. |
1(0,0,0,1) | Details |
| 19034796 | Lee S, Busby AL, Timchalk C, Poet TS: Effects of nicotine exposure on in vitro metabolism of chlorpyrifos in male Sprague-Dawley rats. J Toxicol Environ Health A. 2009;72(2):74-82. |
0(0,0,0,0) | Details |