| Name | E cadherin |
|---|---|
| Synonyms | Arc 1; CAM 120/80; CD324; CD324 antigen; CDH 1; CDH1; CDHE; Cadherin 1… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19151195 | Paleari L, Negri E, Catassi A, Cilli M, Servent D, D'Angelillo R, Cesario A, Russo P, Fini M: Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment. Am J Respir Crit Care Med. 2009 Jun 15;179(12):1141-50. Epub 2009 Jan 16. RATIONALE: Studies strongly suggest that the nicotinic acetylcholine receptors for nicotine (nAChRs) play a significant role in lung cancer predisposition and natural history. METHODS: (1) To check the correlation between alpha7-nAChR presence and alpha-cobratoxin (alpha-CbT) sensitivity, binding experiments were performed in various normal human cells, lung cancer cell lines, and primary tumoral cells; (2) to demonstrate that alpha-CbT might be an efficient adjuvant therapy for non-small cell lung cancer (NSCLC) we expanded our previous observations to a panel of NSCLCs of various subtypes orthotopically grafted on nonobese diabetic/severe combined immunodeficient mice; (3) to gain insight into the mechanism of alpha-CbT-induced tumor reduction, the cells obtained after enzymatic digestion of tumors were analyzed for procaspase-9, Bax, Bad, and Bcl-X (L) protein; and (4) Snail/E-cadherin expression was evaluated to acquire information about the chemoresistance of cancer cells to alpha-CbT. |
1(0,0,0,1) | Details |
| 19841737 | Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S: Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One. 2009 Oct 20;4(10):e7524. In addition, nicotine significantly reduced the expression of epithelial markers, E-Cadherin and beta-Catenin as well as the tight junction protein ZO-1; these tumors also showed an increased expression of the alpha (7) nAChR subunit. |
81(1,1,1,1) | Details |
| 20061081 | Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM, Cho CH: Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. Cancer Lett. 2010 Jan 8. Abrogation of 5-LOX repressed featured molecular markers of EMT (inactivation of E-cadherin and activation of transcriptional repressor Snail). |
2(0,0,0,2) | Details |
| 19690163 | Zhang G, Kernan KA, Thomas A, Collins S, Song Y, Li L, Zhu W, Leboeuf RC, Eddy AA: A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. J Biol Chem. 2009 Oct 16;284(42):29050-64. Epub 2009 Aug 18. Silencing of the nAChRalpha1 gene led to significantly fewer interstitial alphaSMA (+) myofibroblasts (2.8 times decreased), reduced interstitial cell proliferation (2.6 times decreased), better tubular cell preservation (E-cadherin 14 times increased), and reduced fibrosis severity (24% decrease in total collagen). Pre-exposure of uPA to the fibroblasts inhibited [(3) H] nicotine binding. |
1(0,0,0,1) | Details |