Protein Information

Name IL8
Synonyms 3 10C; AMCF I; CXC chemokine ligand 8; CXCL 8; CXCL8; Emoctakin; GCP 1; GCP1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19602125 Ho YC, Yang SF, Huang FM, Chang YC: Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotine. J Periodontal Res. 2009 Dec;44(6):760-6. Epub 2009 Jul 8.

The aim of this study was to investigate the expression of interleukin-1, interleukin-8, receptor activator of nuclear factor-kappaB ligand (RANKL), gelatinases and tissue-type plasminogen activator in U2OS cells (from the human osteosarcoma cell line) stimulated with nicotine.
69(0,2,3,4) Details
20337880 Johnson GK, Guthmiller JM, Joly S, Organ CC, Dawson DV: Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures. J Periodontal Res. 2010 Mar 9.

The objective of this study was to evaluate the effect of nicotine and bacterial lipopolysaccharide (LPS) alone and in combination on gingival keratinocyte production of interleukin-1alpha (IL-1alpha) and interleukin-8 (IL-8).
218(2,3,7,8) Details
19158539 Wang H, Buchner M, Moser MT, Daniel V, Schiltenwolf M: The role of IL-8 in patients with fibromyalgia: a prospective longitudinal study of 6 months. Clin J Pain. 2009 Jan;25(1):1-4.

Pain intensity, back function, depression, nicotine/alcohol consumption, and medication were assessed in the patient group and correlated with IL-8 levels.
42(0,1,2,7) Details
19438974 Mahanonda R, Sa-Ard-Iam N, Eksomtramate M, Rerkyen P, Phairat B, Schaecher KE, Fukuda MM, Pichyangkul S: Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells. J Periodontal Res. 2009 Aug;44(4):557-64. Epub 2009 Mar 13.

The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay.
36(0,1,1,6) Details
19769802 Wang JH, Kim H, Jang YJ: Cigarette smoke extract enhances rhinovirus-induced toll-like receptor 3 expression and interleukin-8 secretion in A549 cells. Am J Rhinol Allergy. 2009 Nov-Dec;23(6):e5-9. Epub 2009 Sep 18.

METHODS: Cigarette smoke extract (CSE) was prepared by smoking two commercial cigarettes with filters (0.9-mg of nicotine and 8.5-mg of tar per cigarette).
4(0,0,0,4) Details
19617917 Aldhous MC, Noble CL, Satsangi J: Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS One. 2009 Jul 20;4(7):e6285.

HBD2 production correlated with IL8 production in UC (p <0.001) and with IL10 in CD (p <0.05).
We investigated environmental and genetic influences on HBD2 protein production using ex vivo cultured sigmoid colon biopsies from 69 patients (22 CD, 26 UC, 21 controls) stimulated with lipopolysaccharide (LPS) and/or nicotine for 24 hours.
1(0,0,0,1) Details
19501920 Huang H, Lavoie-Lamoureux A, Lavoie JP: Cholinergic stimulation attenuates the IL-4 induced expression of E-selectin and vascular endothelial growth factor by equine pulmonary artery endothelial cells. Vet Immunol Immunopathol. 2009 Dec 15;132(2-4):116-21. Epub 2009 May 18.

Using primary equine pulmonary artery endothelial cells culture and real-time RT-PCR method, we observed that ACh, nicotine, and muscarine inhibit the expression of E-selectin and vascular endothelial growth factor by endothelial cells stimulated by reIL-4.
The expression of CXCL-8, a potent neutrophil chemotactic cytokine, remained unaffected however.
1(0,0,0,1) Details
20015843 Pickett G, Seagrave J, Boggs S, Polzin G, Richter P, Tesfaigzi Y: Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies. Toxicol Sci. 2010 Mar;114(1):79-89. Epub 2009 Dec 15.

Furthermore, differences in interleukin-8 secretion were observed.
We compared changes in gene expression and cytokine production in primary normal human bronchial epithelial cells following treatment for 18 h with cigarette smoke condensates (CSCs) prepared from five commercial and four research cigarettes, at doses of approximately 4 microg/ml nicotine.
1(0,0,0,1) Details