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Kawasaki H, Eguchi S, Miyashita S, Chan S, Hirai K, Hobara N, Yokomizo A, Fujiwara H, Zamami Y, Koyama T, Jin X, Kitamura Y: Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery. J Pharmacol Exp Ther. 2009 Sep;330(3):745-55. Epub 2009 May 29.
Nicotine stimulates presynaptic nicotinic acetylcholine receptors in perivascular adrenergic nerves and releases unknown transmitter (s) that activate transient receptor potential vanilloid-1 (TRPV1) located on calcitonin gene-related peptide (CGRP)-containing (CGRPergic) nerves, resulting in vasodilation. |
163(2,2,2,3) |
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