Protein Information

Name phosphodiesterase
Synonyms CAMP specific phosphodiesterase variant PDE4A 10; CAMP specific phosphodiesterase variant TM3; CAMP specific phosphodiesterase; Cyclic AMP phosphodiesterase PDE4A11; Cyclic AMP specific phosphodiesterase HSPDE4A10; DPDE 2; DPDE2; PDE 4…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20113502 Xu Y, Zhang Y, Cardell LO: Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. Respir Res. 2010 Jan 29;11:13.
 113(1,2,2,3) Details
19669865 Iida H, Iida M, Takenaka M, Fukuoka N, Dohi S: Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats. J Thromb Thrombolysis. 2009 Aug 11.

Here, our aim was to investigate the comparative effects of two antiplatelet drugs used for stroke-prevention [a phosphodiesterase-3 inhibitor (cilostazol) and a cyclooxygenase inhibitor (aspirin)] on smoking-induced endothelial dysfunction in cerebral arterioles.
After 1-min smoking (1 mg-nicotine cigarette), the arteriolar responses to ACh were reexamined.		 1(0,0,0,1) Details