Protein Information

Name SIDS
Synonyms Alpha L iduronate sulfate sulfatase; IDS; IDS protein; Iduronate 2 sulfatase; Iduronate 2 sulfatase precursor; Iduronate 2 sulphatase; Idursulfase; MPS II…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19473189 Campos M, Bravo E, Eugenin J: Respiratory dysfunctions induced by prenatal nicotine exposure. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1205-17. Epub 2009 May 19.

Nicotine is likely the link between maternal tobacco smoking and SIDS.
83(1,1,1,3) Details
19091979 Eugenin J, Otarola M, Bravo E, Coddou C, Cerpa V, Reyes-Parada M, Llona I, von Bernhardi R: Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: a probable link to sudden infant death syndrome. J Neurosci. 2008 Dec 17;28(51):13907-17.

Nicotine is a neuroteratogen and is the likely link between maternal cigarette smoking during pregnancy and sudden infant death syndrome (SIDS).
82(1,1,1,2) Details
19651654 Coddou C, Bravo E, Eugenin J: Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice. Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2527-35.

Nicotine may link cigarette smoking during pregnancy with sudden infant death syndrome (SIDS).
82(1,1,1,2) Details
19729586 Duncan JR, Garland M, Myers MM, Fifer WP, Yang M, Kinney HC, Stark RI: Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome. J Appl Physiol. 2009 Nov;107(5):1579-90. Epub 2009 Sep 3.

Thus increased risk for SIDS due to maternal smoking may be partly related to the effects of nicotine on 5-HT and/or nicotinic receptors.
38(0,1,2,3) Details
20198379 Poetsch M, Czerwinski M, Wingenfeld L, Vennemann M, Bajanowski T: A common FMO3 polymorphism may amplify the effect of nicotine exposure in sudden infant death syndrome (SIDS). Int J Legal Med. 2010 Mar 3.
12(0,0,1,7) Details
19498418 Shao XM, Feldman JL: Central cholinergic regulation of respiration: nicotinic receptors. . Acta Pharmacol Sin. 2009 Jun;30(6):761-70.

As perinatal nicotine exposure may contribute to the pathogenesis of sudden infant death syndrome (SIDS), we discuss the effects of perinatal nicotine exposure on development of the cholinergic and other neurotransmitter systems involved in control of breathing.
7(0,0,1,2) Details
19114412 Blood-Siegfried J, Bowers MT, Lorimer M: Is shock a key element in the pathology of sudden infant death syndrome (SIDS)?. Biol Res Nurs. 2009 Oct;11(2):187-94. Epub 2008 Dec 28.

This is exacerbated by perinatal nicotine exposure, a condition shown to alter the autonomic response in exposed offspring.
6(0,0,0,6) Details
19255805 Thiriez G, Bouhaddi M, Mourot L, Nobili F, Fortrat JO, Menget A, Franco P, Regnard J: Heart rate variability in preterm infants and maternal smoking during pregnancy. Clin Auton Res. 2009 Jun;19(3):149-56. Epub 2009 Mar 3.

OBJECTIVE: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS).
The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied.
2(0,0,0,2) Details
19169678 Einarson A, Riordan S: Smoking in pregnancy and lactation: a review of risks and cessation strategies. Eur J Clin Pharmacol. 2009 Apr;65(4):325-30. Epub 2009 Jan 24.

MEDLINE, EMBASE, PUBMED, and Web of Science databases were searched for studies published in English from 1966 to 2008 that reported on smoking in pregnancy and breastfeeding, with information on adverse effects and on all forms of smoking cessation, including behavioral interventions, nicotine replacement therapy, and pharmacotherapy such as antidepressants.
These adverse effects include infertility, ectopic pregnancy, spontaneous abortion, placenta insufficiency, low birth weight, fetal growth restriction, preterm delivery, orofacial clefts, SIDS, craniosynostosis, clubfoot, childhood respiratory disease, attention deficit disorder, and some childhood cancers.
1(0,0,0,1) Details
19896527 Browne CJ, Sharma N, Waters KA, Machaalani R: The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstem. Int J Dev Neurosci. 2010 Feb;28(1):1-7. Epub 2009 Nov 5.

Exposure to cigarette smoke is a major risk factor for sudden infant death syndrome (SIDS).
1(0,0,0,1) Details
19536509 Fu XW, Spindel ER: Recruitment of GABA (A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung. Adv Exp Med Biol. 2009;648:439-45.

The interaction of the intrinsic GABAergic system in the lung with nicotinic receptors in PNEC/NEB may provide a mechanism to explain the link between smoking during pregnancy and SIDS.
1(0,0,0,1) Details
20189133 Blood-Siegfried J, Rende EK: The long-term effects of prenatal nicotine exposure on neurologic development. J Midwifery Womens Health. 2010 Mar-Apr;55(2):143-52.

0(0,0,0,0) Details