Protein Information

Name DRD3
Synonyms D(3) dopamine receptor; D3DR; DRD 3; DRD3; Dopamine receptor D3; Dopamine receptor D3 isoform a; ETM 1; ETM1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19995481 Khaled MA, Farid Araki K, Li B, Coen KM, Marinelli PW, Varga J, Gaal J, Le Foll B: The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking. Int J Neuropsychopharmacol. 2010 Mar;13(2):181-90. Epub 2009 Dec 9.

SB 277011-A (1-10 mg/kg) was able to block cue-induced reinstatement of nicotine-seeking, indicating that DRD3 selective antagonism may be an effective approach to prevent relapse for nicotine.
33(0,1,1,3) Details
19179847 Le Foll B, Gallo A, Le Strat Y, Lu L, Gorwood P: Genetics of dopamine receptors and drug addiction: a comprehensive review. Behav Pharmacol. 2009 Feb;20(1):1-17.

Addictive substances, such as opioids, ethanol, psychostimulants and nicotine, induce pleasant states or relieve distress, effects that contribute to their recreational use.
Here, we will review the information collected implicating the receptors of the D1 family (DRD1 and DRD5) and of the D2 family (DRD2, DRD3 and DRD4) in drug addiction.
1(0,0,0,1) Details