Protein Information

Name p50
Synonyms ARHGEF 7; PAK3; p85; p50; ARHGEF7; BETA PIX; COOL 1; COOL1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19961902 Knott V, Millar A, Fisher D, Albert P: Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine D2 receptor gene polymorphism. Neuroscience. 2010 Mar 10;166(1):145-56. Epub 2009 Dec 2.

Evidence of normalized auditory P50 suppression with acute nicotine in schizophrenia has supported the contention that elevated smoking rates in this disorder may be an attempt to correct a nicotinic receptor pathophysiology that may underly impaired sensory gating in these patients.
287(3,4,6,7) Details
20001113 Sheppard B, Lehmann J, Cope ZA, Brown RW: Sex differences in nicotine sensitization and conditioned hyperactivity in adolescent rats neonatally treated with quinpirole: role of D2 and D3 receptor subtypes. Behav Neurosci. 2009 Dec;123(6):1296-308.

Conditioned hyperactivity was analyzed on P50 in the same context in a drug-free test.
1(0,0,0,1) Details