| Name | dynorphin |
|---|---|
| Synonyms | Beta neoendorphin; Beta neoendorphin dynorphin; Beta neoendorphin dynorphin precursor; Dynorphin; Enkephalin B; Leu enkephalin; Leumorphin; PDYN… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19806344 | McCarthy MJ, Zhang H, Neff NH, Hadjiconstantinou M: Nicotine withdrawal and kappa-opioid receptors. . Psychopharmacology. 2009 Oct 6. RATIONALE: The synthesis and release of dynorphin are increased in the caudate/putamen (CPU) and nucleus accumbens (NAc) of nicotine-withdrawn mice, suggesting a role in the nicotine abstinence syndrome. |
31(0,1,1,1) | Details |
| 20170672 | Berrendero F, Robledo P, Trigo JM, Martin-Garcia E, Maldonado R: Neurobiological mechanisms involved in nicotine dependence and reward: Participation of the endogenous opioid system. Neurosci Biobehav Rev. 2010 Feb 16. Thus, endogenous enkephalins and beta-endorphins acting on mu-opioid receptors are involved in nicotine-rewarding effects, whereas opioid peptides derived from prodynorphin participate in nicotine aversive responses. |
6(0,0,1,1) | Details |
| 19804796 | Bruijnzeel AW: kappa-Opioid receptor signaling and brain reward function. . Brain Res Rev. 2009 Dec 11;62(1):127-46. Epub 2009 Oct 2. This might explain that in some studies kappa-opioid receptor agonists attenuate nicotine and opioid withdrawal symptomatology. The dynorphin-like peptides have profound effects on the state of the brain reward system and human and animal behavior. |
5(0,0,0,5) | Details |