Protein Information

Name mGlu5
Synonyms GPRC1E; GRM 5; GRM5; MGLUR 5; MGLUR5; MGLUR5A; MGLUR5B; Metabotropic glutamate receptor 5…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19833142 Yararbas G, Keser A, Kanit L, Pogun S: Nicotine-induced conditioned place preference in rats: sex differences and the role of mGluR5 receptors. Neuropharmacology. 2010 Feb;58(2):374-82. Epub 2009 Oct 13.

In a series of experiments, the dose-response curve was obtained, pairings between the drug and initially non-preferred versus preferred compartments were compared, and the involvement of mGluR5 receptors in nicotine-induced CPP was evaluated.
224(2,4,4,4) Details
20021449 Bird MK, Lawrence AJ: Group I metabotropic glutamate receptors: involvement in drug-seeking and drug-induced plasticity. Curr Mol Pharmacol. 2009 Jan;2(1):83-94.


Among the latter are the group I metabotropic glutamate (mGlu1 and mGlu5) receptors that upon activation elevate intracellular calcium levels through activation of the phospholipase C pathway.
2(0,0,0,2) Details